Our “Integrative Muscle Biology Laboratory” (IMB) employs molecular biology techniques with in vivo and in vitro models to examine the regulation of skeletal muscle anabolic and metabolic plasticity. A major focus of our research seeks to improve our understanding of the cellular signaling that integrates muscle mechanical signaling with alterations in systemic inflammation and sex hormone signaling. To this end, we have employed in vivo paradigms of hindlimb disuse, treadmill exercise, muscle stretch, compensatory overload, stimulated concentric contractions, and stimulated eccentric contractions. We have investigated muscle responses to the previously mentioned treatments with physiological systemic disruptions related to aging, ovariectomy, orchiectomy, cancer, and high fat, diet-induced obesity. The IMB lab also has years of experience quantifying mouse muscle molecular signaling, phenotype, and morphology after either exercise or disease treatments. Our research expertise includes physiological modeling in preclinical disease models, and whole- body measurements of function, health and survival in preclinical cancer cachexia models. We also have expertise in a wide range of cellular signaling mechanisms and physiological processes that are relevant to cancer treatments. IMB related research encompasses over 130-refereed publications in journals, such as J Biol Chem, American Physiological Society Journals, Skeletal Muscle, and FASEB Journal. Student mentorship in research has been a cornerstone of the IMB laboratory, and we have actively worked to promote diversity in biomedical research trainees, spanning high school students to post-doctoral fellows.